Kemerovo State University
Russian Federation
Kemerovo, Kemerovo, Russian Federation
from 01.01.2025 until now
VAK Russia 4.1.1
VAK Russia 4.1.2
VAK Russia 4.1.3
VAK Russia 4.1.4
VAK Russia 4.1.5
VAK Russia 4.2.2
VAK Russia 4.2.3
VAK Russia 4.2.4
VAK Russia 4.2.5
VAK Russia 4.3.3
VAK Russia 4.3.5
UDC 616.831
UDC 615.322
UDC 636.7
The aim of the research is to evaluate the effectiveness and safety of the use of various adjuvants during epidural anesthesia in dogs. The study was conducted in the period from 2024–2025 on the basis of the VetDoktor veterinary clinic (Novosibirsk). The protocol of epidural anesthesia was developed taking into account the individual characteristics of the patient, the nature and duration of surgical intervention. The animals were prepared for anesthesia according to a single protocol for all study groups. Before the procedure, the animals had limited access to food for 8–12 hours. For induction, propofol was administered at a dose of 4-6 mg/kg intravenously until the required depth of anesthesia was reached. After induction, endotracheal intubation was performed and the animal was transferred to inhalation anesthesia using isoflurane at a concentration of 1.5–2.5 % in an oxygen stream of 0.1 l/kg/min. The volume of the injected solution was calculated based on the body weight of the animal according to the formula: V (ml) = 0.2 ml/kg × body weight (kg). The effectiveness was assessed according to a set of clinical, physiological and laboratory parameters. The data was recorded at the following stages: initial data (before induction); after induction of anesthesia; after administration of epidural anesthesia (after 5, 15, 30 minutes); intraoperatively (every 15 minutes); in the early postoperative period (after 1, 2, 4, 6, 12, 24 an hour). The use of opioid adjuvants during epidural anesthesia in dogs significantly increases the effectiveness of anesthesia, increasing the duration of analgesia by 1.5–2.3 times compared with the use of local anesthetics without adjuvants. Morphine provides the longest postoperative analgesia (8.2 ± 1.4 hours), but is accompanied by a higher frequency of side effects (urinary retention – 40 %, itching – 30 %). Fentanyl is characterized by a faster onset of action ((11.2 ± 2.4) minutes) and a lower incidence of complications, but a shorter duration of effect ((5.4 ± 0.9) hours); combinations of various local anesthetics with adjuvants demonstrate different efficacy and safety profile.
epidural anesthesia, adjuvant, anesthetic, dogs
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