At newborn calves at emergence of sharp intestinal fmstration of a bacterial origin by the dominating representatives microbiocenosis enteropathogenic strains of E. coli, strains of bacteria of the genera Citrobacter, Proteus, Klebsiella and Enterobacter. In clinically healthy calves dominant position in relation to other groups of bacteria is taken by bifidobacteria and lactobacilli. Carrying out actions of a microbiocenosis optimization of a digestive trad for sharp intestinal frustration of newborn calves prevention is recommended.