Xenobiotic phenylphenol is industrially significant aromatic compounding used as fungicide in the processing of agricul-tural products. The aim of the study was to examine the influ-ence of xenobiotic phenylphenol on the activity of the complex of extracellular lignolytic enzymes Lentinula edodes and the ability to biodegradate phenylphenol with this complex. The research problems were to measure the activity of lignolytic L. edodes enzymes in the course of cultivation at addition of phenylphenol in various concentration; to estimate the accu-mulation of L. edodes biomass at addition of phenylphenol; to establish the decrease in the maintenance of phenylphenol in the environment after cultivation. The object of the research was lignolitic mushroom of L. edodes W4. The cultivation was carried out in a deep way. Phenylphenol was added to the medium at the concentrations of 0.01; 0.1 and 1 mM. The change of activity of phenol-oxidizing enzymes (laccase, pe-roxidase, Mn-peroxidase) was determined in cultural liquid by spectrophotometer; the total amount of phenolic connections in the environment was also determined by spectrophotome-ter using standard method of Folin-Chokaltteu. It was shown that the addition of phenylphenol to the culture medium at the concentration of 0.01 mM increased the activity of laccase by 45 % compared to the control. In contrast, the addition of phenylphenol inhibited the formation of Mn-peroxidase activity which decreased by 2.5 times comparing to control. The addi-tion of phenylphenol also induced the formation of peroxidas-es, but the level of peroxidase activity remained insignificant. It was also established that lignolytic complex of L. edodes enzymes was capable of destroying phenylphenol at fungicide concentrations of up to 0.1 mM. The obtained results allow considering that the ability of phenolic xenobiotics to degrada-tion caused by lignolytic enzymes of Lentinula edodes com-plex is promising for further study.