In the study the efficiency of using protective preparations of chemical and biological origin when processing tubers and plants of potatoes during vegetation in climatic conditions of Primorsky Re-gion was estimated. The results of synthetic pro-tectant Maxim action in complex with preventive pesticide of Tanos, and also natural immunomodulators, i.e. a set of biologically active agents Zircon P are presented, microbiological preparation Fitosporin-M and humic preparation Complex 3 on the formation of vegetative weight, fractional structure and indicators of production of general, commodity and seed potatoes of grade Amber. The existence of close interrelation be-tween general productivity and the area of average leaf of potatoes was proved. The influence of the studied preparations on the formation of the area of a leaf surface and the value of photosynthetic po-tential of landings for vegetation was established. The application of protectant of Maxim when plant-ing potatoes and fungicide of Tanos during vegeta-tion increased the quantity of stalks of plants by 14.3 %, having provided the maximum photosyn-thetic potential equal to 1.82 thousand sq.m of days/hectare. The use of biologically active agents as elements in technologies of potatoes cultivation positively affected the formation of elevated bio-mass, but did not promote active formation of tu-bers. The maximum gross productivity and stand-ard seed material exit was provided by option with application of synthetic protectant Maxim before planting in complex with fungicide Tanos during vegetation 28.8 and 19.8 t/hectare respectively. Using biological active agents did not increase the production of potatoes (25.3-25.6 t/hectare) in comparison with control (26.2 t/hectare). The culti-vation of potatoes without using of protective prep-arations (control) promoted the maximum exit of consumers’ potatoes equal to 5.3 t/hectare.