The aims of the study were to investigate the general biological reactivity of an organism of cattle during various seasons of the year, to establish optimum terms of carrying out allergic researches on tuberculosis in the conditions of the Far East and to develop the technological scheme of tuberculosis prevention in cattle. In the analysis of an epizootic situation on tuberculosis of cattle methods of epizootic researches were used. At animals indicators of the general protein in serums of blood were refractometrically determined by standard techniques. As a result of the conducted researches, taking into account features of an epizootic situation and immune diagnosis of tuberculosis of cattle, carried-out earlier and also during special researches, we developed and offered veterinary experts the concept of the technological scheme of tuberculosis prevention in cattle. The possibilities of an organism of animals to adapt, i.e. to adapt to the stresses caused by change of keeping conditions are limited to quite narrow framework. Within preservation of optimum dynamic constancy of the internal environment of an organism process of adaptation is accompanied with serious stress that undoubtedly affects efficiency, and after a long period of time leads to disorder of physiological functions and frequently results in their failure. Thus, at allergic researches of cattle on tuberculosis the organism is capable to give more adequate answer to introduction of tuberkulin during the autumn and winter periods (from October to Febmary) that allows to reveal the animals infected with the causative agent of tuberculosis. It is established that diagnosis of tuberculosis in spring is unreliable as by the end of winter immune responsiveness of cattle sharply decreases, and in summer not always manages to restore. The concept of the technological scheme of prevention of tuberculosis of cattle in the conditions of the Far East is developed.